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The favorable results from the placebo-controlled FLOW trial, conducted with semaglutide 1.0 mg in patients with T2D and chronic kidney disesase (CKD), are about to be disclosed, while ongoing dedicated trials will further explore the effects of OW semaglutide 2.4 mg (NCT04889183) and tirzepatide (NCT05536804) on kidney function parameters in obese/overweight individuals at high risk of CKD progression regardless of T2D

However, patient preference for oral therapies has limited early-line use of GLP-1s

Semaglutide, a glucagon-like peptide-1 receptor ( GLP-1 ) agonist, works by activating GLP-1 receptors throughout the body , including the pancreas, gut, and brain

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